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And except you have a physician-diagnosed deficiency in any of those nutrients that you simply can’t fill with meals alone, there’s no real have to supplement in any respect. "At finest, tremendous-excessive doses of nutrients are buying you expensive urine, and at worst, they might contribute to the development of chronic diseases," she says. While research show supplementing with excessive doses does assist construct muscle mass and increase energy over time, it’s not pre-workout in the strict sense, in that timing doesn’t actually matter. Taking smaller doses extra steadily throughout the day could also be an option, but you should focus on any modifications in your medication timing or dosage together with your physician earlier than experimenting on your own. For instance, a 2017 study within the Journal of Clinical Oncology found that lengthy-term supplementation with high doses of vitamin B6 and B12 may significantly improve the danger of lung cancer in men